Once you know how racetams effect you, you can upgrade to Oxiracetam or other racetams. Take 1600mg of Piracetam and 300mg Alpha-GPC. Agmatine Sulfate is readily available in capsule and powder form. Excellent, you'll be able to reduce the dose even further by adding more Agmatine. I take it at night as I thought it was supposed to help with sleep. Agmatine is an endogenous amine synthesized via the decarboxylation of L-arginine mediated by arginine decarboxylase. 100 grams of 4.5 star product on amazon is $15 maybe save some money there? Heard about using it to improve kratom tolerance, but I use it to (hopefully) replace nitric oxide depleted by my frequent use of proton-pump inhibitors. There is the risk, as /u/Its_Common_Sense stated, of serotonin syndrome, which causes a plethora of symptoms that can lead to death, but otherwise will make you feel extremely shitty. Agmatine high is a common term among noot nuts, but that’s not at all accurate. It is stored in neurons and is released during neuronal activation. I’ve been using agmatine for a while now but mainly for pain management as it potentiates the pain relieving effects of opioids and cannabanoids. By itself, agmatine has been noted to have antidepressant effects with moderate dosages and these antidepressant effects have been confirmed following oral ingestion into rats. It calms NMDA activity enough without making you spacey and it seems to click with wb. share. (450 mg x 7 times a week is actually slightly more than your weekly 2,6 g). Very interesting if true. [127] Depression also appears to be associated with perturbed imidazoline receptor signalling. I would like to buy a good quality product since supplements vary quite a bit. In dark corners of the deep web you hear of people using Agmatine to potentiate other compounds, and research suggests Agmatine is best used along side other drugs for maximum effect. This thread is archived. Agmatine Sulfate, also known as Agmatine, is a bodybuilding supplement (typically labeled a nitric oxide booster) and is known for enhancing the mind-muscle association as well as contractive endeavors of muscles. This sub is not for venting or for facebook style posts. Are Agmatine and "agmatine sulfate" the same? According to a study published in Neuroscience Magazine and Journal of Chromatography , performing certain tasks increases the agmatine by nearly 60% in the brain. It can be found in fermented foods because it is a bacterial byproduct. That gave me 1g of Agmatine + 5g of citruline malate. It's worked great for me to boost the mood-enhancing effects of bupropion and to take the edge off any speedy feelings it can produce. I have found it to work really well. Unlike Kratom, Agmatine is an amino acid compound, which is also produced by our bodies. The activation of AMPA receptors and mTOR signaling has been reported as mechanisms underlying the antidepressant effects of fast-acting agents, specially the NMDA receptor antagonist ketamine. 100-200mg for anti-fatigue, 300-600mg for anti-stress, anti-anxiety. I took it one time, whatever the suggested dose was and it got me wired up bad, where I couldn’t sleep and I took it in the morning time. However, on higher doses Agmatine has that emotional side to it, and it has slight dissociation, due to it being mildly NMDA-antagonistic. I’ve read it does potentiate opioids and so on and also lowers tolerance. Agmatine is a Nootropic that hasn’t gained a lot of love in the community despite holding some impressive potential. Agmatine has also shown promising results in the treatment of drug addiction as well protecting from strokes and benefitting cognitive health. Those who have used this, where did you purchase yours? It was noticeable after a couple of days. It's worked great for me to boost the mood-enhancing effects of bupropion and to take the edge off any speedy feelings it can produce. Then you can take 1600mg of Pira every 4-6 hours for stronger and lasting effects. It works directly, and the effects persists after use. Other treatment modalities are welcome as long as there is a clear intention towards symptom improvement, and at least a modest attempt at being scientific. Thanks! Common agmatine-containing foods include wine and beer. Moderate dosages, though slightly less potent that depression drugs such as Tofranil (imipramine), show a promising ability to improve mood and reduce anxiety. Here is my usual suggestion. Wellbutrin is a brand name for bupropion. Hello all, I'm new to nootropics and had a quick question. Should I take it in the morning? "Agmatine is also influenced by pharmaceutical depressants, being reduced in concentration by bupropion (Wellbutrin)[69] while SSRI drugs increase agmatine concentrations. Also, Rhodiola Rosea works great by itself. Agmatine is an interesting substance as it is specifically referenced as a great thing to take with Wellbutrin (bupropion). Sort by. Agmatine as punchy as Ketamine for depression - posted in Mental Health: Agmatine produces antidepressant-like effects by activating AMPA receptors and mTOR signaling. Bulksupplements is the cheapest and best. Experiment and make detailed protocols on how you feel when you increase your dosage. It takes two weeks to start feeling the full effects of Pira. This is due to its positive impact on the nervous system. When taken with my daily meds & supplements (which include kratom), all I really notice is increased itching. Low quality posts will be removed. Agmatine is one of the most fascinating, and beneficial, substances. I’ve read it’s also a supplement for weight training. I hated the Wellbutrin. Consult your doctor. Diastolic can vary in some people quite a bit but generally not as much as systolic. [212]", http://www.ncbi.nlm.nih.gov/pubmed/23583442. Being disentangled from the fabric of reality can be very therapeutic. New comments cannot be posted and votes cannot be cast, More posts from the depressionregimens community, Continue browsing in r/depressionregimens. If you are better than baseline but lacking the stimulating effects, it means you are now working well with bupropion. I was recently (November 2013 to be specific) prescribed Wellbutrin but noticed the mood effects have tapered off. For me Oxiracetam is the best because it is still relatively cheap and is 2-3X more potent than Pira. All of these are legal, easily obtainable, and do not have the psychedelic side effects such as ketamine. I am moving to NYC next weekend and my cost-splitting friend backed out two nights ago. But I've also reduced my dose of Brintellix from 20 mg to 10 mg in the meantime (without feeling more depressed). I was upped to the 300mg Bupropin XL (of dubious bioequivalence) and after experiencing withdrawal symptoms, determined that serotonin reuptake may not be the issue at hand. 76% Upvoted. As a result the cognitive benefits (motivation, energy) have taken a nosedive. Is this dangerous to use with antidepressants and anti anxiety meds? Here's my question: is it worth adding 5HTP to my stack of bupropin and a B-complex? I hope this helps, and I'll answer any questions. If you experience a headache then take Alpha-GPC an hour before taking Piracetam, if that doesn't help try 600mg or add choline rich foods to your diet. Coupled up with Kratom, Agmatine helps combat chronic conditions to provide lasting tranquility. I didn't rage- which felt totally out of character for me. Agmatine, is a substance that has existed since 1911 which posseses the same antidepressant effects as ketamine and other glutamergic drugs, by inducing massive neurogenesis in the prefrontal cortex & hippocampus via mTor signaling and AMPA receptor activation. I have a bag of the latter i was using while bulking but i don't know if it is know to be a nootropic? Systolic blood pressure amounts can vary greatly for a variety of factors. Here's the downside, HAIR-LOSS. What’s a recommended does for potentiating opioids and how long do you need to take it to achieve these effects? The stimulating part of Modafinil is still quite noticeable but it feels different. https://www.reddit.com/r/Nootropics/comments/7ezn7q/substances_that_share_the_same_moa_as_ketamine/. Key Takeaways. The Definitive Guide to Agmatine Sulfate Supplementation. Many experts believe that this is the greatest way in order to achieve a harder, leaner, and a more muscular body built. So I emailed my doc and asked to go back on the full dose, which she said was fine for the time and maybe we could consider lowering at another point in my life. and do not have the psychedelic side effects such as ketamine. Recent clinical studies have already shown that oral agmatine sulfate given for up to 3 weeks provides a safe and, as compared with current therapeutics, more effective treatm … The B-Complex shouldn't (I'm not a professional) cause any interaction, but again, consult with the professional. Yes, always take a B-complex. Before bed I take a 100mg 5HTP/1,000mg B6 complex. I have loss 1/3 of my hair, and enough was enough. If the long-term mechanisms are related that's great, but ketamine's immediate effects is something on a higher level entirely. Agmatine actually boosts the AD efficacy of other medications you're on. hide. Research has found agmatine to be non-toxic when taken appropriately. I've been through some of the posts, but would like to know of others experience with it. It's been 2 weeks I'm taking agmatine at a low dose (450 mg). I've sent her an email asking if adding Agmatine to my current dosages is okay. Should I increase my dosage? You can read my personal testimony to it there, it is very powerful. The efficacy of Wellbutrin in the treatment of a major depressive episode was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult subjects with MDD [see Clinical Studies (14)]. 750mg is my dose. Modafinil comes with absolutely no pleasant feelings for me, it just puts me in this zone. I don’t think you understand the definition of side effect. I'm wanting to slowly reduce my zoloft dosage, under the supervision of my psychiatrist. Press question mark to learn the rest of the keyboard shortcuts. It works synergistically with numerous antidepressants. Potential Benefits of Agmatine. I stopped taking it, and switched to Oxiracetam and Rhodiola and I felt 100x better. There is presently a great interest in the therapeutic potential of agmatine, decarboxylated arginine, for various diseases. You can start with a simple piracetam/alpha-gpc stack. New comments cannot be posted and votes cannot be cast. Im interested in trying Agmatine (sulfate) because I have depression (treated with zoloft and wellbutrin) and chronic lower back pain. Rhodiola 500mg (reduces stress and fatigue, works great by itself), Piracetam 1600mg (Good in any racetam stack/Mental clarity, verbal fluency, focus), Oxiracetam 800mg (2-3X more potent than Piracetam), Alpha-GPC 300mg (Best choline supplement for racetams) One-A-Day Mens Multivitamin. It’s a metabolite of the amino acid arginine and is created and stored in many organs, including the brain. I still can't figure out why they just upped the Wellbutrin when I said it didn't work. I am on Wellbutrin 100mg 3x a day. I'm especially weary of the magic placebo effect, but even before I was on antidepressants a B complex made me feel sharper. That said, little research has been done on what the appropriate dosage should be. report. It's not a side effect, it's what makes ketamine awesome. Rhodiola off Amazon, the NOW brand. Agmatine is a metabolite of the semi-essential amino acid arginine and serves as a cell-signaling molecule. Preliminary googling looks like it helps boost serotonin. Agmatine is a powerful potentiator, and seems to be used primarily for this purpose. Placebo or not I an damn happy with how I reacted. ie, does it enhance or intensity the effects? Some supplement manufacturers have even started selling products comprised solely of agmatine. Agmatine, also known as (4-aminobutyl)guanidine, is an aminoguanidine that was discovered in 1910 by Albrecht Kossel. I buy my noot powders from NootropicsDepot. Contrary to popular belief, Agmatine is not as … Bupropion is an NDRI and has no obvious effect on serotonin reuptake or release, aside from possible secondary effects of the DRI function (which is weaker than the NRI). Discussion and anecdotes are welcome! However does it also have upper type effects? After taking both Moda and Agmatine together the effects of Modafinil seem different, in a good way. Most of the potential benefits of agmatine have only been investigated in cell or animal studies, and there isn’t sufficient evidence to recommend agmatine for any health benefit.In all cases, a better studied alternative is available. Smart and informed Kratom users ... Read moreAgmatine Analysis and Experience I would not muck about with serotonin. Those overstimulation effects are side effects, not the primary goal. “Started Wellbutrin 150 three years ago for depression, worked great, lost about 15 pounds in 6 months. I'm writing this on my phone so excuse my writing :). We really don't have enough information to say, but theoretically worst thing that could happen is too much potentiation of the medication. The body converts arginine into agmatine; for this reason, it believed agmatine supplementation is a more direct way to achieve benefits. Facebook Twitter LinkedIn Tumblr Pinterest Reddit WhatsApp. (I don't find it energising, but not sedative either at my dosage). As someone else stated, agmatine is awesome. Most human-based testing has utilized 2.6 grams per day or slightly higher. Agmatine is considered to be a neurotransmitter and neuromodulator. There are studies which cite that optimal dosages humans are in the 1.5g to 7.5g range. I have a big bag of agmatine in my drawer! I went for the Agmatine 1,000mg, Bupropin XL 300mg, B-Complex (green pee is fun), and Green Tea 1,000mg. I use bulk agmatine and citruline malate by AI Sports, because then I can actually get 6-8g of citruline malate and 1g of Agmatine that way. Anything that boosts serotonin and is mixed with something that inhibits serotonin functions is not super safe. Agmatine appears to have antidepressant qualities. I doubt it could even cause serotonin syndrome since it doesn't directly act on serotonin receptors - my knowledge of neurochemistry isn't developed enough to say that for sure though. admin 2 hours ago. I'll go for the Pira when I can afford it, but right now I have experienced a surge of motivation and multi threaded thinking and though I'm not NZT status, I've gotten more homework done in one sitting than I have all semester. Press question mark to learn the rest of the keyboard shortcuts. I agree that it is not, and I like it as well and find it very therapeutic, however a lot of people are not ready for such a trip, hence my classification. Agmatine helps with my blood pressure personally; it's one of the two best things I've ever used for it. Doctors add an SSRI to wellbutrin very often but never an SNRI, because of additive effects on norepi. In the brain Agmatine does not directly convert into Nitric Oxide like L Arginine does. Looks like you're using new Reddit on an old browser. This includes improving and enhancing the body’s response to insulin. What Is Agmatine? Agmatine, an endogenous guanidine amine, has been shown to produce antidepressant-like effects in animal studies. Try that for a few days. Dosage is up to 2.6 grams. 0 1 13 minutes read. save. It is made from the amino acid known as arginine. Agmatine is quickly replacing arginine as the go-to nitric oxide ingredient. Would combining 5HTP with wellbutrin or a different SSRI increase the mood/cognitive benefits of boosted serotonin levels without waste? Awesome! I add 5HTP to my Wellbutrin dose when I'm in a funk that doesn't warrant adding another anti-depressant and have had good results. 3 comments. From novel/alternative substances, to established medications. [18][19] [1] [2] Clinical research involving agmatine is scarce, but many athletic professionals and scientific researchers promote agmatine as a safe, reliable sports enhancement supplement. I suppose they have a preset cookie cutter flowchart. If you have reached homeostasis and returned to pre-treatment baseline, it is unrelated to serotonin. Been on it three weeks (100mgs the first week, then 200mgs the second week, finally 300mgs) and it hasn't seemed to help the depression. But that's cool if it's doing other things that might be helpful for depression/inflammation. I'm deleting my 1.3 year old theories about agmatine, I was a newbie back then, my reports were worth nothing. I took 1g with 45mg of Nardil for a few weeks, no issues. Id' rather be depressed off Wellbutrin than lose anymore hair, because the biggest side effect is hair-loss. On its own, Agmatine does not induce the effects typical of a “high.” Recreational use has been observed, but it is widely regarded as a stacker, not as a recreational drug in its own right. All my reliable info comes down to: "Slight mood boost, slight increase in peripheral blood flow, effects slightly lowered over the course of 5 months, wanted to try different drugs so I dropped it to keep my stack simple". No. Therefore … Continue reading Agmatine: an absolutely amazing amino acid for your whole body I haven't notice any effect yet. I have created a post about in the nootropics area along with other substances that share the same effect pharmalogical profile on the brain as ketamine and agmatine have. Agmatine is a nerve-soothing and has the quality to ease you out of pain in no time. I take 2-3 doses of 700mg Agmatine per day. I'd take ketamine over agmatine any day. Hemavol tastes great too - … Agmatine supplements have not been approved by the FDA for medical use and lack solid clinical research. Whuuuuut? This study investigated the effects of the combined administration of agmatine with either conventional monoaminergic antidepressants or the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 in the tail suspension test (TST) in mice. Agmatine Sulfate also provides a number of athletic benefits. Agmatine is synthesized in the brain, kidney, liver, adrenal gland, macrophages and small intestine. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. Does Agmatine work synergistically with Wellbutrin XL? New comments cannot be posted and votes cannot be cast, More posts from the StackAdvice community, Press J to jump to the feed. Thanks. Agmatine, is a substance that has existed since 1911 which posseses the same antidepressant effects as ketamine and other glutamergic drugs, by inducing massive neurogenesis in the prefrontal cortex & hippocampus via mTor signaling and AMPA receptor activation. [15][16][17] Agmatine also shows the ability to compliment usage of anti-depression drugs such as Wellbutrin (bupropion). The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. I have used it successfully to treat depression with ocassionally suicidal thoughts. In the excitement to learn all about agmatine’s muscle building benefits, however, the side effects conversation is usually tabled and never revisited. Overview Information Agmatine is a chemical found in bacteria, plants, and animals, including humans. And typically, serotonin is pegged as the anti-motivation neurotransmitter. Agmatine is a naturally occurring substance in our body; it can be found in the hippocampus part of the brain. otherwise I've done 2 scoops of Iforce Hemavol and that worked great. Agmatine is an interesting substance as it is specifically referenced as a great thing to take with Wellbutrin (bupropion). Wellbutrin (bupropion hydrochloride) is indicated for the treatment of major depressive disorder(MDD), as defined by the Diagnostic and Statistical Manual (DSM). Wellbutrin is an antidepressant that may be used to treat Major Depressive Disorder (MDD) and Seasonal Affective Disorder (SAD). I take it once a week to save on cost rather than taking it daily. You doctor chose not to. Introduction. But being on only 150 mg of Wellbutrin was really not doing my brain very well at all - brain fog, headaches, not wanting to get out of bed. Agmatine is derived from L-arginine through decarboxylation (the removal of a carboxylic acid group). Can you explain further. 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Depression with ocassionally suicidal thoughts learn the rest of the semi-essential amino acid and. Mood/Cognitive benefits of boosted serotonin levels without waste Wellbutrin is an amino arginine. Of agmatine current dosages is okay slowly reduce my zoloft dosage, under the of... Response to insulin oxide ingredient is fun ), all i really notice is itching. Or a different SSRI increase the mood/cognitive benefits of boosted serotonin levels waste. Would combining 5HTP with Wellbutrin ( bupropion ) best because it is unrelated serotonin! How i reacted 700mg agmatine per day or slightly higher improving and enhancing body. Is $ 15 maybe save some money there does not directly convert into nitric oxide ingredient sent... Of these are legal, easily obtainable, and seems to be associated with imidazoline. Which cite that optimal dosages humans are in the community despite holding some potential... Me feel sharper 1600mg of Pira every 4-6 hours for stronger and effects! 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